Biography
I-Harry Cretedelister ngugqirha waseMelika onesiphi isifundo esiqhutywa kwicandelo le-endocrinogy kunye neRheumatology. Ugqirha wayefuna iindlela zonyango eziza kunceda ukoyisa ubunxila, kwaye baba ngumbuyiso wokuphambuka ngenxa yendibaniselwano ekhethekileyo ye-chromosome emzimbeni womntu. Isifaniso sabizwa ngokuba yiKlinfelter Syndrome.Ubuntwana noLutsha
UHarry wazalwa ngoMatshi 20, 1912 kwisixeko saseBaltimore, esikwiMaryland. Abazali bakaHarry noElizabhete uClannfelter bavelisa abantwana abathathu. Iyeza elizayo iyeza lifumene imfundo esemgangathweni. Ngo-1937 waba ngumdlalo weyunivesithi yaseJones Hopkin kwidolophu yakhe.
Ukuziqhelanisa nezonyango Klanfelter Jr. Kwaqala ngo-1941 njengomncedisi webrinte. Kwiminyaka embalwa, umfana othile wasebenza kwikliniki yaseMassachusetts.
Ukususela ngo-1943 ukuya ku-1946, uHarry wayekhonza emkhosini, emva koko wabuyela eBaltimore kwakhona, apho wayehlala khona kunyango lwezigulana yiprofayile. Wayefundisa kwisikolo sezonyango, kunye nokwenza uphando kwicandelo leRheumatology nakwi-Endocrinogy.
Ubomi Buqu
UHarry Klinfelter wadlala indima ebalulekileyo kwinkcazo yesifo semfuzo yemfuzo engafakwanga, kodwa yaziwa kancinci ngebhayiloji kagqirha. Ukonwaba kubomi bobuqu inzululwazi efumaneka emtshatweni kunye ne-Elaine Klanfelter. Umtshato wenzeka ngo-1943 eMissouri. U-Elaine wayeyindawo ye-elaine. Umfazi wanika uHarry abantwana abathathu.Umsebenzi
Ukuqala ukufunda ukuphambuka okungaqhelekanga kunye ne-Endocrinogist ye-Endorbrinogist ye-Endorbright Albright ngo-1941, uKregnelkelter, uCregnFelter walungelelanisa iqela lamadoda alithoba. Uhlalutyo oluthathwe kwizigulana zibonise inani lokuphambuka. Phakathi kwazo, GyneAmiastia, i-spermatogenes kunye nethamo egqithisileyo yeholiti yehormoni.
Ugqirha ucebise ukuba unobangela wesi sifo sisifo esiphazamisayo, kodwa sele singowe-1959 lo mgwebo waphuculwa. Izizathu zokuphambuka ukusukela ngoko azithathwa njenge-Hormonal, kodwa i-chromosomes.
Phakathi kweempawu zesifo se-syndrome, efunde i-Connfelter, bubukhulu bama-testicles. Ngo-1942, le nezinye iimpawu zesifo seminyango zichazwe kwinqaku elithi "iphephandaba le-Endocrinology". Ukusuka kwelo xesha, ukhathazeka kwaqala ukubizwa ngokuba yimbeko kumphandi.
Ngokutsho kukagqirha, bekunokwenzeka ukuba uchonge isifo esikhundleni senqanaba lokuqala. Ngexesha lokuhlolwa, egcinwe ngamakhwenkwe, waphawula amanqaku empikog yabo. Ngalo lonke ixesha, esi sifo safunyanwa kubafana abaselula esineempawu eziqhelekileyo zesondo esiqhelekileyo kunye nesiqhelo sisebenza ngesondo. Emva koko, kwatyhilwa ukuba i-gyneastia ayisoloko ihamba iphawu ehamba-ntetho ehamba nalo i-clonfelter syndrome.
Emva kweminyaka eli-14 emva kwezifundo zokuqala, kwacaca ukuba izigulana ezinengxaki ye-endocrine yayinama-47 chromosomes. Bafumene i-paticle ye-X, okanye i-complate apho indibaniselwano ye-XXY yayikhona. Isimilo sine-chromosome enye yohlobo olunye okanye olunye uhlobo. Ke, inani elincinci leKardotypes livela, eliqala kakhulu. I-chromatin elungileyo ikwabhekisa kwinani lemiqondiso efunyenwe ekufunyanisweni kwe-Clonfelther Syndrome. Izigulana ezinesifo esinjalo sibangelwa kukungachumi.
Isiphene esichongwe yi-harry cretefter sibandakanyiwe kuluhlu lwe-genetics edumileyo. I-pathology ichaphazela i-0,2% yamadoda kwiplanethi. Ukongeza, esi sifo se-Endocrine sithathwa njengeyona nto ifunyaniswayo emva kokuba iswekile emva kweswekile kunye nehlelo le-hland.
Ukuguquguquka kwenziwe yi-syndrome ayikufunyanwa njengelifa, ukuba kukho umntwana othile entsatsheni enesifo esinjalo, akunakulindeleka ukuba kufunyanwe. I-Neuch ayifane ineempawu ezibonakalayo. Nangona ezinye izigulana ziphawula ububanzi beenwele, inani elincinci leenwele emzimbeni kunye nesifuba esandisiweyo. Kwiimeko ezinqabileyo, iingxaki zokufunda okanye zokuthetha ziyavela. Ukuchonga ubukho besi sifo kwiintsana okanye abantwana abasandul 'ingenakwenzeka, njengoko kubonakaliswa ngexesha lokufikisa. Kodwa kukho ithuba lokuvavanya ngokugqithisileyo de umntwana abonakale.
IHarry Clainfeller icetywayo ukumisela unyango lwe-testosterone's agences, enegalelo kuphuhliso lwesondo. Xa isetyenziswa ngexesha lokufikisa, ibhalansi inokufezekiswa kwaye ize nomzimba kuphuhliso oluqhelekileyo. Akunakwenzeka ukunyanga ukuphazamiseka kude kube sekupheleni, kuba ukophulwa kwemfuza akunakulungiswa. Kodwa ukunciphisa iimpawu kwaye ugcine indoda kwizimanzi ezikhoyo. Phambi kwesifo sengqondo esinjalo, sokukhulelwa, babhenela ekuchumeni kwawo.
Ukufa
UHarry Klinfelter wasweleka ngoFebruwari 20, 1990. Unobangela wokusweleka kogqirha akachazwanga, kodwa kusenokwenzeka ukuba wayenxulunyaniswa nokwaluphala kwendoda endala eneminyaka engama-77. Ukuzahlulela umsebenzi wokufunda kwesinye sesona siphambuko esidumileyo sofuzo esifumaneka kule nkulungwane yama-20, ugqirha wenza igalelo elibalulekileyo kuphuhliso lwesayensi. Namhlanje, ifoto ye-endocrinologist ipapasha kwiincwadi zesikhokelo zaseyunivesithi.